Obesity leads to an inflammatory condition that is directly involved in the etiology of
cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function.
Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function …

The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …

Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate …

Summary Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but
the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor …

Background: Replacing SFAs with vegetable PUFAs has cardiometabolic benefits, but the
effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been …

Nonalcoholic fatty liver disease (NAFLD) is recognized as the leading cause of chronic liver
disease in adults and children. NAFLD encompasses a spectrum of liver injuries ranging …