Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

Gynecological malignancies are a significant cause of morbidity and mortality across the
globe. Due to delayed presentation, gynecological cancer patients are often referred late in …

Despite advances in immuno-oncology, the relationship between tumor genotypes and
response to immunotherapy remains poorly understood, particularly in high-grade serous …

Several patient-derived tumor models emerged recently as robust preclinical drug-testing
platforms. However, their potential to guide clinical therapy remained unclear. Here, we …

Reciprocal interactions between prostate cancer cells and carcinoma‐associated fibroblasts
(CAFs) mediate cancer development and progression; however, our understanding of the …

Prognosis stratification in colorectal cancer helps to address cancer heterogeneity and
contributes to the improvement of tailored treatments for colorectal cancer patients. In this …

Globally the incidence of hepatocellular carcinoma (HCC) is on an upsurge. Evidence is
accumulating that liver disorders like nonalcoholic fatty liver disease (NAFLD) and its more …

Purpose: We recently reported that the transcription factor NFATC4, in response to
chemotherapy, drives cellular quiescence to increase ovarian cancer chemoresistance. The …

Resistance to chemotherapy is a long-standing problem in the management of cancer, and
cancer stem cells are regarded as the main source of this resistance. This study aimed to …

Background Previous preclinical studies have shown that activin A is overexpressed in
malignant pleural mesothelioma (MPM), associates with cancer cachexia, and is observed …