Pulmonary arterial (PA) hypertension (PAH) is a severe cardiopulmonary disease that may
be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions …

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with increased risk
of cerebrovascular stroke, and with several other pathologies, including heart failure …

Introduction: Although there have been important technological advances for the treatment
of cardiac arrhythmias (eg, catheter ablation technology), antiarrhythmic drugs (AADs) …

Aims Atrial fibrillation (AF) with concomitant heart failure (HF) is associated with prolonged
atrial refractoriness. Small-conductance, calcium-activated K+(K Ca, KCNN) channels …

In the wake of demographic change in Western countries, atrial fibrillation has reached an
epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack …

Serine/threonine protein phosphatases control dephosphorylation of numerous cardiac
proteins, including a variety of ion channels and calcium-handling proteins, thereby …

The TASK-1 channel belongs to the two-pore domain potassium channel family. It is
expressed in several cells of the heart, including the right atrial (RA) cardiomyocytes and the …

Atrial fibrillation (AF), the most frequent cardiac arrhythmia, is associated with increased
morbidity and mortality. 1 Currently available pharmacologic interventions for AF have major …

The human heart responds to various diseases with structural, mechanical, and electrical
remodelling processes. These changes may initially compensate functional impairment …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …