TRAAK is a mechanosensitive two-pore domain K+(K2P) channel localized to nodes of
Ranvier in myelinated neurons. TRAAK deletion in mice results in mechanical and thermal …

Cardiac electrophysiology and mechanics are strongly interconnected. Their interaction is,
among others, mediated by mechano‐electric feedback through stretch‐activated ion …

Atrial fibrillation (AF) is a condition in which the electrical signals in the upper heart
chambers (atria) are rapid and disorganized, producing an irregular and chaotical heartbeat …

Introduction: Atrial fibrillation (AF) is the most common arrhythmia in humans. It is
progressive and the development of electrical and structural remodeling makes early …

Atrial fibrillation (AF) is the most common clinical arrhythmia disorder. It can easily lead to
complications such as thromboembolism, palpitations, dizziness, angina, heart failure, and …

Mechano-electric feedback is one of the most important subsystems operating in the
cardiovascular system, but the underlying molecular mechanism remains rather unknown …

Abstract Background/Aims: The two-pore-domain potassium channel TASK-1 regulates
atrial action potential duration. Due to the atrium-specific expression of TASK-1 in the human …

Loss of function KCNK3 mutation is one of the gene variants driving hereditary pulmonary
arterial hypertension (PAH). KCNK3 is expressed in several cell and tissue types on both …

Sleep apnea is a highly prevalent disorder with increasing impact on healthcare systems
worldwide. Previous studies have been conducted primarily with male subjects, and …

Electrical remodelling as a result of homeodomain transcription factor 2 (Pitx2)-dependent
gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide …