Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression
R Busch, CH Rinderknecht, S Roh… - Immunological …, 2005 - Wiley Online Library
In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …
Binding interactions between peptides and proteins of the class II major histocompatibility complex
BJ McFarland, C Beeson - Medicinal research reviews, 2002 - Wiley Online Library
The activation of helper T cells by peptides bound to proteins of the class II Major
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …
The kinetic stability of MHC class II: peptide complexes is a key parameter that dictates immunodominance
CA Lazarski, FA Chaves, SA Jenks, S Wu, KA Richards… - Immunity, 2005 - cell.com
T cell priming to exogenous antigens reflects regulated antigen processing in dendritic cells,
subsequent homing to lymph nodes, sustained interactions between T cells and antigen …
subsequent homing to lymph nodes, sustained interactions between T cells and antigen …
[图书][B] Allergic contact dermatitis: chemical and metabolic mechanisms
C Smith - 2023 - taylorfrancis.com
llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and
protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and …
protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and …
Determination of the HLA-DM interaction site on HLA-DR molecules
Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
CA Painter, MP Negroni… - Proceedings of the …, 2011 - National Acad Sciences
HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …
HLA-DM, HLA-DO and tapasin: functional similarities and differences
In both the MHC class II and class I pathways of antigen presentation, accessory molecules
influence formation of MHC–peptide complexes. In the MHC class II pathway, DM functions …
influence formation of MHC–peptide complexes. In the MHC class II pathway, DM functions …
Ovalbumin(323−339) Peptide Binds to the Major Histocompatibility Complex Class II IAd Protein Using Two Functionally Distinct Registers
Proteins of the class II major histocompatibility complex (MHC) bind antigenic peptides that
are subsequently presented to T cells. Previous studies have shown that most of the …
are subsequently presented to T cells. Previous studies have shown that most of the …
HLA-DM targets the hydrogen bond between the histidine at position β81 and peptide to dissociate HLA-DR–peptide complexes
The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …
histocompatibility (MHC) class II molecules during antigen processing; however, the …
Amino-terminal flanking residues determine the conformation of a peptide–class II MHC complex
SB Lovitch, Z Pu, ER Unanue - The Journal of Immunology, 2006 - journals.aai.org
The peptide spanning residues 48–62 of hen egg white lysozyme presented by IA k
molecules gives rise to two T cell populations, types A and B, that recognize distinct …
molecules gives rise to two T cell populations, types A and B, that recognize distinct …