Human leukocyte antigen-DM (HLA-DM) is an integral component of the major
histocompatibility complex class II (MHCII) antigen-processing and-presentation pathway …

HLA-DRβ1* 0101-HA and HLA-DRβ1* 0401-HA complexes are studied and compared by
means of their computationally derived multipolar moments and electrostatic potentials …

Proteins must be stable to accomplish their biological function and to avoid enzymatic
degradation. Constitutive proteolysis, however, is the main source of free amino acids used …

The structural basis for antigen presentation by class II major histocompatibility complex
(MHC) proteins to CD4+ T-cells is important for understanding and possibly treating …

The adaptive immune response starts when CD4+ T cells recognize peptide antigens
presented by class II molecules of the Major Histocompatibility Complex (MHCII). Two …

Abstract IE/DR MHC class II molecules have an extensive H-bonding network under the
bound peptide. In IE k, two α chain acidic amino acids in the core of this network were …

Introduction 3. MHC class II synthesis and assembly with chaperones 4. Biochemical and
structural characterization of DM 5. The molecular mechanism of DM function 5.1 …

The recognition by CD 4+ T cells of peptides bound to class II MHC (MHC II) molecules
expressed on the surface of antigen‐presenting cells is a key step in the initiation of an …

We present a new method to explore interactions between peptides and major
histocompatibility complex (MHC) molecules using the resultant vector of the three principal …

Major Histocompatibility Complex class II (MHC-II) molecules bind peptides and present
them to receptors on CD4+ T cells as part of the immune system's surveillance of pathogens …