This study investigated the phenotype and magnitude of the CD4+ T lymphocyte response to
HCV to see if there was any correlation with the severity of the resultant liver disease. In …

Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at
mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-Ek revealed …

Recognition of peptides bound to class II major histocompatibility complex (MHCII)
molecules by T cell receptors of CD4+ T cells initiates an adaptive immune response …

Antigen presentation and recognition are key processes of the immune system necessary to
initiate the adaptive immune response. Longstanding goals of these fields have been to …

Moleküle des Haupthistokompatibilitätskomplexes (MHC) präsentieren Antigenpeptide für
die Überwachung durch T-Zellen und sind somit ein zentraler Bestandteil der adaptiven …

MHC II proteins are heterodimeric glycoproteins that form complexes with antigenic peptides
in order to elicit a CD4+ adaptive immune response. Even though there have been …

The Immunodominance of CD4 T Cell Epitopes is Peptide Intrinsic: Implications for Rational
Vaccine Design Page 1 The Immunodominance of CD4 T Cell Epitopes is Peptide Intrinsic …

In antigen presenting cells, MHC class II molecules bind peptide fragments and present
them to CD4+" helper" T cells. The antigen processing pathway in these cells involves a …

Establishment of an immune response that is focused on a limited number of peptide
determinants expressed by a complex antigen or pathogen is a phenomenon known as …

Abbreviations: CHO, Chinese hamster ovary; CLIP, class II invariant chain-derived peptide;
DDM, n-dodecyl maltoside; HA, hemagglutinin; HPLC, high-performance liquid …