Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a
dysregulated host response to infection. The main etiological causes of sepsis are bacterial …

The host response to COVID-19 pathophysiology over the first few days of infection remains
largely unclear, especially the mechanisms in the blood compartment. We report on a …

Irisin is an exercise-induced myokine that alleviates inflammation and obesity. The induction
of anti-inflammatory (M2) macrophage is facilitated for treatment of sepsis and associated …

Rapid, sensitive, simultaneous quantification of multiple biomarkers in point-of-care (POC)
settings could improve the diagnosis and management of sepsis, a common, potentially life …

Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly
characterised. Brain pathology in SAE, which is manifested by impaired perception …

The acute phase reaction is a systemic response to acute or chronic inflammation. The
serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in …

Treatments that target single mediators of sepsis have failed to reduce its high mortality rate.
Here we developed multifunctional tannic acid-Zn 2+-gentamicin nanoparticles (TA-Zn-Gen …

Key homeostasis providing cells in the central nervous system (CNS) are astrocytes, which
belong to the class of cells known as atroglia, a highly heterogeneous type of neuroglia and …