There is currently no specific and effective treatment for bacteremia-mediated sepsis. Hence,
this study engineered a combinatorial nanosystem containing neutrophil-targeted roflumilast …

Objectives To assess the effects of empiric antibiotics with different degrees of
appropriateness based on hospital cumulative antibiograms in patients with bacteraemic …

Background Matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinases-
1 (TIMP-1) have been shown to predict prognosis in sepsis. However, MMP-8 and TIMP-1 in …

Sepsis is a dysregulated host response to infection that causes potentially life-threatening
organ dysfunction. We investigated the serum metabolomic profile at hospital admission for …

Calcineurin–nuclear factor of activated T cells (CN-NFAT) inhibitors are widely clinically
used drugs for immunosuppression, but besides their required T cell response inhibition …

Sepsis is described as a systemic immune response of the body to an infectious process that
might result in dysfunctional organs that may lead to death. In clinical practice, sepsis is …

Rationale Heterogeneity of the host response within sepsis, acute respiratory distress
syndrome (ARDS) and more widely critical illness, limits discovery and targeting of …

Proinflammatory cytokines like interleukin-1β (IL-1β) affect the control of breathing. Our aim
is to determine the effect of the anti-inflammatory cytokine IL-10 οn the control of breathing …

(1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid
clinical deterioration and organ dysfunction. The cholinergic system has been implicated in …

Sepsis causes an activation of the human contact system, an inflammatory response
mechanism against foreign surfaces, proteins and pathogens. The serine proteases of the …