Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Malignant cells exhibit metabolic changes, when compared to their normal counterparts,
owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has …

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …

Summary Cyclic GMP-AMP synthase (cGAS) is an essential DNA virus sensor that triggers
type I interferon (IFN) signaling by producing cGAMP to initiate antiviral immunity. However …

Although certain therapeutic agents with immunogenic properties may enhance antitumor
immunity, cancer cells can eliminate harmful cytoplasmic entities and escape …

Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all
human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing …

Osteoimmunomodulation has informed the importance of modulating a favorable
osteoimmune environment for successful materials-mediated bone regeneration …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

The present paradigms of selective autophagy in mammalian cells cannot fully explain the
specificity and selectivity of autophagic degradation. In this paper, we report that a subset of …

The phosphorylation of eIF2α is essential for the endoplasmic reticulum (ER) stress
response, the formation of stress granules, as well as macroautophagy. Several successful …