Combinatorial strategies for the induction of immunogenic cell death

L Bezu, LC Gomes-da-Silva, H Dewitte… - Frontiers in …, 2015 - frontiersin.org
The term “immunogenic cell death”(ICD) is commonly employed to indicate a peculiar
instance of regulated cell death (RCD) that engages the adaptive arm of the immune system …

Functions of autophagy in the tumor microenvironment and cancer metastasis

EE Mowers, MN Sharifi, KF Macleod - The FEBS journal, 2018 - Wiley Online Library
Macro‐autophagy is an ancient and highly conserved self‐degradative process that plays a
homeostatic role in normal cells by eliminating organelles, pathogens, and protein …

Dedicated SNARE s and specialized TRIM cargo receptors mediate secretory autophagy

T Kimura, J Jia, S Kumar, SW Choi, Y Gu… - The EMBO …, 2017 - embopress.org
Autophagy is a process delivering cytoplasmic components to lysosomes for degradation.
Autophagy may, however, play a role in unconventional secretion of leaderless cytosolic …

The Crohn's disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy

S Mehto, KK Jena, P Nath, S Chauhan, SP Kolapalli… - Molecular cell, 2019 - cell.com
Several large-scale genome-wide association studies genetically linked IRGM to Crohn's
disease and other inflammatory disorders in which the IRGM appears to have a protective …

Autophagy and viral infection

J Mao, E Lin, L He, J Yu, P Tan, Y Zhou - Autophagy regulation of innate …, 2019 - Springer
Autophagy is an intracellular recycling process that maintains cellular homeostasis by
orchestrating immunity upon viral infection. Following viral infection, autophagy is often …

AMPK: a key regulator of energy stress and calcium-induced autophagy

R Saikia, J Joseph - Journal of Molecular Medicine, 2021 - Springer
Autophagy is a well-known cell-survival strategy orchestrated by a conserved set of proteins.
It equips the cells with mechanisms to attain homeostasis during unfavorable conditions …

Research progress of microneedles in the treatment of melanoma

X Li, Z Zhao, M Zhang, G Ling, P Zhang - Journal of controlled release, 2022 - Elsevier
Melanoma is an aggressive malignancy deriving from melanocytes, which is characterized
by high tendency of metastases and mortality rate. Current therapies for melanoma, like …

On‐demand autophagy cascade amplification nanoparticles precisely enhanced oxaliplatin‐induced cancer immunotherapy

X Wang, M Li, K Ren, C Xia, J Li, Q Yu, Y Qiu… - Advanced …, 2020 - Wiley Online Library
Chemoimmunotherapy‐induced antitumor immune response is highly dependent on tumor
autophagy. When tumor cells are treated with chemoimmunotherapy, timely overactivated …

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

CR Figueiredo, H Kalirai, JJ Sacco… - The Journal of …, 2020 - Wiley Online Library
Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in
many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver …

Autophagy and kidney inflammation

T Kimura, Y Isaka, T Yoshimori - Autophagy, 2017 - Taylor & Francis
Inflammation plays a pivotal role in pathophysiological processes of kidney diseases.
Macroautophagy/autophagy plays multiple roles in inflammatory responses, and the …