Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the
lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance …

Hyperuricemia has become a common metabolic disease, and is a risk factor for multiple
diseases, including chronic kidney disease. Our recent study indicated that following …

Immunotherapy has attracted widespread attention in cancer treatment and has achieved
considerable success in the clinical treatment of some tumors, but it has a low response rate …

Excessive and prolonged activation of macrophages underlies many inflammatory and
autoimmune diseases. To regulate activation and maintain homeostasis, macrophages have …

Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to
inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes …

Alpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts
and has developed multiple strategies to counteract the host defense. Here, we demonstrate …

The osteoimmune environment plays indispensable roles in bone regeneration because the
early immune environment that exists during the regenerative process promotes the …

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release
of ATP is associated with immunogenic cancer cell death as well as inflammatory responses …