The efficacy of statin treatment on cognitive decline is controversial, and the effect of statins
on cognitive deficits in individuals with traumatic brain injury (TBI) has yet to be investigated …

Abstract Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
commonly used to reduce serum cholesterol. The beneficial effects of oral simvastatin have …

Currently available epilepsy drugs only affect the symptoms (seizures), and there is a need
for innovative treatments that target the underlying disease. Increasing evidence points to …

Despite the high incidence of brain injuries in children, we have yet to fully understand the
unique vulnerability of a young brain to an injury and key determinants of long-term …

Delirium is a clinical syndrome characterized by a temporary organic mental disorder, as
well as abnormal attention and cognition. It is a very common, serious, and costly disease …

Lumbar spinal stenosis (LSS) is the leading cause of morbidity and mortality worldwide. LSS
pathology is associated with secondary injury caused by inflammation, oxidative damage …

Background Several in-vitro and animal studies suggest that statins may have beneficial
effects on clinical outcomes of traumatic brain injury (TBI), however, clinical data are scarce …

Drug repurposing, known as drug repositioning, is considered a method for redeveloping a
compound to utilize in a distinctive illness, which is now becoming a progressively critical …

There is controversy on the effect of statins on cognitive functions such as spatial memory. In
the present study, effect of tenday oral gavage of rosuvastatin (Ros, 20 mg/kg) on spatial …

PURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and
memory of rats, as a reflection of the administration of a minimum dose capable of …