Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …

The importance of RNA methylation in biological processes is an emerging focus of
investigation. We report that altering m6A levels by silencing either N 6-adenosine …

Background—Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies.
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …

Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor
development and growth by promoting the formation of a neoplastic environment. The recent …

We show that the splicing regulator PTBP2 controls a genetic program essential for neuronal
maturation. Depletion of PTBP2 in developing mouse cortex leads to degeneration of these …

Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each
pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB …

Pulmonary arterial hypertension (PAH) is a severe and increasingly prevalent disease,
manifested by the maladaptation of pulmonary vasculature, which consequently leads to …

Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein
involved in several post-transcriptional regulatory events of gene expression. Initially …

Recent investigations have highlighted the importance of the non-coding genome in regions
of hypoxia in tumours. Such regions are frequently found in solid tumours, and are …