Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic
regions of brain thought to be responsible for long-term behavioral plasticity driving …

The striatum plays a key role in mediating the acute and chronic effects of addictive drugs,
with drugs of abuse causing long-lasting molecular and cellular alterations in both dorsal …

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …

This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens
(NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental …

Learning to inhibit drug seeking can be an important strategy for inhibiting relapse, and this
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …

Exposure to drugs of abuse, such as cocaine, leads to plastic changes in the activity of brain
circuits, and a prevailing view is that these changes play a part in drug addiction. Notably …

Abstract In 1993, Robinson and Berridge published their first review that laid out the
incentive sensitization theory of addiction (Robinson and Berridge 1993 Brain Res Rev 18 …

Experience-dependent plasticity at excitatory synapses of the mesocorticolimbic system is a
fundamental brain mechanism that enables adaptation to an ever-changing environment …

Exposure to addictive drugs causes changes in synaptic function within the striatal complex,
which can either mimic or interfere with the induction of synaptic plasticity. These synaptic …

The importance of glutamate in the reinstatement of cocaine-seeking behavior has been
established. New molecular and neurochemical adaptations in the glutamatergic system …