Aminoglycosides, a class of clinically important drugs, are widely used worldwide against
gram-negative bacterial infections. However, there is growing evidence that …

Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of
the auditory system. However, they are vulnerable to genetic defects, noise exposure …

Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with
liposomes can effectively reduce friction. However, the lubrication can be inactivated when …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Background Increasing evidence shows that circular RNAs (circRNAs), a novel class of
noncoding RNAs, play a crucial role in the development of cancers, including intrahepatic …

Hydrogel microrobots have blazed new avenues for local drug administration, while their
values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic …

Background: Cisplatin is a widely used anti-tumor agent but its use is frequently limited by
nephrotoxicity. Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation …

Radiotherapy is the standard adjuvant treatment for glioma patients; however, the efficacy is
limited by radioresistance. The function of Interleukin-1 receptor associated kinase 1 …

Neuroinflammation plays important roles in the pathogenesis and progression of altered
neurodevelopment, sensorineural hearing loss, and certain neurodegenerative diseases …

The disruption of oxidation-reduction equilibrium through inhibiting reactive oxygen species
(ROS) clearance or enhancing ROS production has emerged as a novel and promising …