Mechanism and prevention of ototoxicity induced by aminoglycosides
X Fu, P Wan, P Li, J Wang, S Guo, Y Zhang… - Frontiers in cellular …, 2021 - frontiersin.org
Aminoglycosides, a class of clinically important drugs, are widely used worldwide against
gram-negative bacterial infections. However, there is growing evidence that …
gram-negative bacterial infections. However, there is growing evidence that …
Autophagy regulates the survival of hair cells and spiral ganglion neurons in cases of noise, ototoxic drug, and age-induced sensorineural hearing loss
L Guo, W Cao, Y Niu, S He, R Chai… - Frontiers in Cellular …, 2021 - frontiersin.org
Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of
the auditory system. However, they are vulnerable to genetic defects, noise exposure …
the auditory system. However, they are vulnerable to genetic defects, noise exposure …
Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis
Y Lei, Y Wang, J Shen, Z Cai, C Zhao, H Chen… - Science …, 2022 - science.org
Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with
liposomes can effectively reduce friction. However, the lubrication can be inactivated when …
liposomes can effectively reduce friction. However, the lubrication can be inactivated when …
Unveiling the mechanisms and challenges of cancer drug resistance
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …
treatment strategies are evolving due to innate and acquired resistance capacity, governed …
CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma
W Liao, J Du, L Li, X Wu, X Chen, Q Feng, L Xu… - Journal of Experimental …, 2023 - Springer
Background Increasing evidence shows that circular RNAs (circRNAs), a novel class of
noncoding RNAs, play a crucial role in the development of cancers, including intrahepatic …
noncoding RNAs, play a crucial role in the development of cancers, including intrahepatic …
Magnetic hydrogel microrobots delivery system for deafness prevention
H Chen, H Zhang, Y Dai, H Zhu, G Hong… - Advanced Functional …, 2023 - Wiley Online Library
Hydrogel microrobots have blazed new avenues for local drug administration, while their
values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic …
values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic …
[HTML][HTML] TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy
B Yu, L Jin, X Yao, Y Zhang, G Zhang, F Wang, X Su… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Cisplatin is a widely used anti-tumor agent but its use is frequently limited by
nephrotoxicity. Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation …
nephrotoxicity. Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation …
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells
J Li, Y Sun, X Zhao, Y Ma, Y Xie, S Liu, B Hui… - Cell Death & …, 2023 - nature.com
Radiotherapy is the standard adjuvant treatment for glioma patients; however, the efficacy is
limited by radioresistance. The function of Interleukin-1 receptor associated kinase 1 …
limited by radioresistance. The function of Interleukin-1 receptor associated kinase 1 …
Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β‐Catenin and Sonic Hedgehog Pathways
J Huang, L Zhou, J Chen, T Chen, B Lei… - Neural …, 2021 - Wiley Online Library
Neuroinflammation plays important roles in the pathogenesis and progression of altered
neurodevelopment, sensorineural hearing loss, and certain neurodegenerative diseases …
neurodevelopment, sensorineural hearing loss, and certain neurodegenerative diseases …
Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer
Y Bai, C Liang, J Zhou, Y Liu, F Wang, J Gao… - European Journal of …, 2023 - Elsevier
The disruption of oxidation-reduction equilibrium through inhibiting reactive oxygen species
(ROS) clearance or enhancing ROS production has emerged as a novel and promising …
(ROS) clearance or enhancing ROS production has emerged as a novel and promising …