Targeting the heat shock response induced by modulated electro-hyperthermia (mEHT) in cancer

P Viana, P Hamar - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Abstract The Heat Shock Response (HSR) is a cellular stress reaction crucial for cell survival
against stressors, including heat, in both healthy and cancer cells. Modulated electro …

Non-thermal membrane effects of electromagnetic fields and therapeutic applications in oncology

P Wust, U Stein, P Ghadjar - International Journal of Hyperthermia, 2021 - Taylor & Francis
The temperature-independent effects of electromagnetic fields (EMF) have been
controversial for decades. Here, we critically analyze the available literature on non-thermal …

[HTML][HTML] Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

PHL Viana, CA Schvarcz, LO Danics, B Besztercei… - Scientific Reports, 2024 - nature.com
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast
cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted …

Enhancing therapeutic efficacy in triple‐negative breast cancer and melanoma: synergistic effects of modulated electro‐hyperthermia (mEHT) with NSAIDs especially …

N Giunashvili, JM Thomas, CA Schvarcz… - Molecular …, 2024 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a leading cause of cancer mortality and lacks
modern therapy options. Modulated electro‐hyperthermia (mEHT) is an adjuvant therapy …

[HTML][HTML] The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

SY Lee, G Lorant, L Grand, AM Szasz - Cancers, 2023 - mdpi.com
Simple Summary Modulated electro-hyperthermia (mEHT) is a heating therapy that uses
synergized thermal and nonthermal effects to heat and destroy malignant cells selectively …

[HTML][HTML] Combined effects of hyperthermia and chemotherapy on the regulate autophagy of oral squamous cell carcinoma cells under a hypoxic microenvironment

F Shi, D Luo, X Zhou, Q Sun, P Shen, S Wang - Cell death discovery, 2021 - nature.com
Autophagy has a complex dual role in tumor survival or cell death owning to that is an
evolutionarily conserved catabolic mechanism and provides the cells with a sustainable …

[HTML][HTML] Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor

WFA Wan Mohd Zawawi, MH Hibma, MI Salim… - Scientific reports, 2021 - nature.com
Breast cancer is the most common cancer that causes death in women. Conventional
therapies, including surgery and chemotherapy, have different therapeutic effects and are …

[HTML][HTML] External basic hyperthermia devices for preclinical studies in small animals

MI Priester, S Curto, GC van Rhoon, TLM Ten Hagen - Cancers, 2021 - mdpi.com
Simple Summary The application of mild hyperthermia can be beneficial for solid tumor
treatment by induction of sublethal effects on a tissue-and cellular level. When designing a …

Digoxin-Mediated Inhibition of Potential Hypoxia-Related Angiogenic Repair in Modulated Electro-Hyperthermia (mEHT)-Treated Murine Triple-Negative Breast …

SMZ Bokhari, K Aloss, PH Leroy Viana… - ACS Pharmacology & …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer type with no
targeted therapy and hence limited treatment options. Modulated electrohyperthermia …

[HTML][HTML] Modulated Electro-Hyperthermia Accelerates Tumor Delivery and Improves Anticancer Activity of Doxorubicin Encapsulated in Lyso-Thermosensitive …

K Aloss, SMZ Bokhari, PH Leroy Viana… - International Journal of …, 2024 - mdpi.com
Modulated electro-hyperthermia (mEHT) is an adjuvant cancer therapy that enables tumor-
selective heating (+ 2.5° C). In this study, we investigated whether mEHT accelerates the …