Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of
dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly …

Mitochondrial metabolism is an attractive target for cancer therapy,. Reprogramming
metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers …

Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …

Cancer is often considered a genetic disease. However, much of the enormous plasticity of
cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …

The process of epithelial-to-mesenchymal transition (EMT) is an essential type of cellular
plasticity associated with a change from epithelial cells that function as a barrier consisting …

Ferroptosis is an iron-dependent programmed cell death event, whose regulation and
physiological significance remain to be elucidated. Analyzing transcriptional responses of …

The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most
mammalian tissues and functions primarily as a transcriptional suppressor by …

Motivation Single cell transcriptional profiling opens up a new avenue in studying the
functional role of cell-to-cell variability in physiological processes. The analysis of single cell …

The progression of cancer involves not only the gradual evolution of cells by mutations in
DNA but also alterations in the gene expression induced by those mutations and input from …