Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

Abstract Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation
that plays a complex, and sometimes contrasting, role in different stages of cancer …

American tegumentary leishmaniasis is a vector-borne parasitic disease caused by
Leishmania protozoans. Innate immune cells undergo long-term functional reprogramming …

Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the
parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells …

Patients infected with Leishmania braziliensis develop chronic lesions that often fail to
respond to treatment with antiparasite drugs. To determine whether genes whose …

As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …

Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging
to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis …

Kinetoplastid parasites have caused human disease for millennia. Significant achievements
have been made toward developing new treatments for leishmaniasis (particularly on the …

Cutaneous leishmaniasis causes alterations in the skin microbiota, leading to pathologic
immune responses and delayed healing. However, it is not known how these microbiota …

Background Keratinocytes can function as innate immune cells under oxidative stress and
aggravate the cutaneous T-cell response that undermines melanocytes in the setting of …