Protein conjugation with ubiquitin and ubiquitin-like small molecules, such as UFM1, is
important for promoting cancer cell survival and proliferation. Herein, the development of the …

Mutation of the gene encoding ubiquitin‐like modifier‐activating enzyme 5 (UBA5) causes
autosomal recessive early‐onset epileptic encephalopathy. UBA5 acts as an E1‐activating …

Subverting the conventional concept of “the” ribosome, a wealth of information gleaned from
recent studies is revealing a much more diverse and dynamic ribosomal reality than has …

Recently, increased attention has been focused on the regulatory mechanism and potential
clinical application of ferroptosis in cancer cells, especially therapy-related ferroptosis …

All ubiquitin‐like proteins (UBLs) undergo an activation process before their conjugation to
target proteins. Although the steps required for the activation of UBLs are conserved and …

Ubiquitin fold modifier 1 (UFM1) is a member of the ubiquitin-like protein family. UFM1
undergoes a cascade of enzymatic reactions including activation by UBA5 (E1), transfer to …

Immunotherapy of PD-L1/PD-1 blockage elicited impressive clinical benefits for cancer
treatment. However, the relative low response and therapy resistance highlight the need to …

Ufm1 (ubiquitin-fold modifier 1) is the most recently identified member of the ubiquitin-like
protein family. We characterized the Ufm1 cascade of the model organism Caenorhabditis …

Post-translational modification represents an important mechanism to regulate protein
function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of …

Post‐translational modification is a rite of passage for cellular functional proteins and
ultimately regulate almost all aspects of life. Ubiquitin‐fold modifier 1 (UFM1) system …