Exposure of cells or organisms to chemicals can trigger a series of effects at the regulatory
pathway level, which involve changes of levels, interactions, and feedback loops of …

Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Mass spectrometry is well-established as one of the primary methods used to characterize
peptides and proteins. New advances in instrumentation and innovative analytical workflows …

Nitric oxide (NO), a free radical, plays a critical role in a wide range of physiological and
pathological processes. Due to its pleiotropic function, it has been widely investigated in …

Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics …

Protein post-translational modification (PTM) is a regulatory mechanism for protein activity
modulation, localization, expression, and interactions with other cellular molecules. It …

Significant technical advancements in phosphopeptide enrichment have enabled the
identification of thousands of p-peptides (mono and multiply phosphorylated) in a single …

Studying the stress response is a major pillar of neuroscience research not only because
stress is a daily reality but also because the exquisitely fine-tuned bodily changes triggered …

Copper nanoclusters (CuNCs) with bright blue-emitting fluorescence have been synthesized
via a simple one-pot process using 2-mercapto-1-methylimidazole (MMI) as a stabilizer. The …

More than 300 different protein post‐translational modifications are currently known, but only
a few have been extensively investigated because modified proteoforms are commonly …