Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized,
immobile epithelial cells lose tight junctions, associated adherence, and become migratory …

The spatiotemporal organization and dynamics of chromatin play critical roles in regulating
genome function. However, visualizing specific, endogenous genomic loci remains …

Large-scale chromosome structure and spatial nuclear arrangement have been linked to
control of gene expression and DNA replication and repair. Genomic techniques based on …

Understanding the topological configurations of chromatin may reveal valuable insights into
how the genome and epigenome act in concert to control cell fate during development …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Most genomic variants associated with phenotypic traits or disease do not fall within gene
coding regions, but in regulatory regions, rendering their interpretation difficult. We collected …

Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a
century their internal organization remains largely unsolved. We applied chromosome …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

We describe Hi-C, a method that probes the three-dimensional architecture of whole
genomes by coupling proximity-based ligation with massively parallel sequencing. We …