Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders
C Gutiérrez-Rodelo, SE Martínez-Tolibia… - Molecular Biology …, 2023 - Springer
Anxiety and depression disorders are highly prevalent neurological disorders (NDs) that
impact up to one in three individuals during their lifetime. Addressing these disorders …
impact up to one in three individuals during their lifetime. Addressing these disorders …
[HTML][HTML] Comparative Efficacy of Animal Depression Models and Antidepressant Treatment: A Systematic Review and Meta-Analysis
P Ratajczak, J Martyński, JK Zięba, K Świło… - Pharmaceutics, 2024 - mdpi.com
Background: Animal models are critical tools in the study of psychiatric disorders; however,
none of the current models fully reflect human stress-related disorders, even though most of …
none of the current models fully reflect human stress-related disorders, even though most of …
Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies
Although there are various treatments available for depression, some patients may
experience resistance to treatment or encounter adverse effects. Centella asiatica (C …
experience resistance to treatment or encounter adverse effects. Centella asiatica (C …
Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via 1H Nuclear …
Depression is a common mental disorder that can adversely affect psychosocial function
and quality of life. However, the exact aetiology and pathogenesis of depression are still …
and quality of life. However, the exact aetiology and pathogenesis of depression are still …
A systems biology-based mathematical model demonstrates the potential anti-stress effectiveness of a multi-nutrient botanical formulation
A Saxena, KS Prabhudesai, A Damle… - Scientific Reports, 2024 - nature.com
Stress is an adaptive response to the stressors that adversely affects physiological and
psychological health. Stress elicits HPA axis activation, resulting in cortisol release …
psychological health. Stress elicits HPA axis activation, resulting in cortisol release …
Centella asiatica (L.) Urban. attenuates cell damage in hydrogen peroxide-induced oxidative stress in transgenic murine embryonic stem cell line-derived neural-like …
Background: Centella asiatica (L.)(C. asiatica) is commonly known in South East and South
East Asia communities for its nutritional and medicinal benefits. Besides being traditionally …
East Asia communities for its nutritional and medicinal benefits. Besides being traditionally …
Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila …
Common symptoms of depressive disorders include anhedonia, sleep problems, and
reduced physical activity. Drugs used to treat depression mostly aim to increase serotonin …
reduced physical activity. Drugs used to treat depression mostly aim to increase serotonin …
Neuroprotective Action of Selected Natural Drugs Against Neurological Diseases and Mental Disorders: Potential Use Against Radiation Damage
Akhlada, N Siddiqui, Anurag, A Saifi… - Neurochemical …, 2024 - Springer
Exposure to radiation, ionizing and non-ionizing radiation, is a significant concern in modern
society. The brain is the organ that is most sensitive to radiation exposure. This review …
society. The brain is the organ that is most sensitive to radiation exposure. This review …
Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration
NE Gray, W Hack, MS Brandes, JA Zweig, L Yang… - Frontiers in …, 2024 - frontiersin.org
Background: A water extract (CAW) of the Ayurvedic plant Centella asiatica administered in
drinking water has been shown to improve cognitive deficits in mouse models of aging and …
drinking water has been shown to improve cognitive deficits in mouse models of aging and …
Antidepressant-like properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
NU Abdul Aziz, SM Chiroma, MA Mohd Moklas… - Brain sciences, 2020 - mdpi.com
Pathophysiology of postpartum depression (PPD) has been associated with many factors,
such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) …
such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) …