Advancing therapy for neuroblastoma

B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Overview of the 2022 WHO classification of paragangliomas and pheochromocytomas

O Mete, SL Asa, AJ Gill, N Kimura, RR de Krijger… - Endocrine …, 2022 - Springer
This review summarizes the classification of tumors of the adrenal medulla and extra-
adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and …

[HTML][HTML] Recent advances in the developmental origin of neuroblastoma: an overview

M Ponzoni, T Bachetti, MV Corrias, C Brignole… - Journal of Experimental …, 2022 - Springer
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

[HTML][HTML] Neuroblastoma: When differentiation goes awry

M Zeineldin, AG Patel, MA Dyer - Neuron, 2022 - cell.com
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

[HTML][HTML] Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis

IS Fetahu, W Esser-Skala, R Dnyansagar… - Nature …, 2023 - nature.com
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Schwann cell precursors represent a neural crest‐like state with biased multipotency

ME Kastriti, L Faure, D Von Ahsen… - The EMBO …, 2022 - embopress.org
Schwann cell precursors (SCPs) are nerve‐associated progenitors that can generate
myelinating and non‐myelinating Schwann cells but also are multipotent like the neural …

[HTML][HTML] A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung

A Sountoulidis, S Marco Salas, E Braun, C Avenel… - Nature Cell …, 2023 - nature.com
The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

[HTML][HTML] Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

C Thirant, A Peltier, S Durand, A Kramdi… - Nature …, 2023 - nature.com
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

[HTML][HTML] A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

A Laddach, SH Chng, R Lasrado, F Progatzky… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data

L Faure, R Soldatov, PV Kharchenko… - …, 2023 - academic.oup.com
Abstract Summary scFates provides an extensive toolset for the analysis of dynamic
trajectories comprising tree learning, feature association testing, branch differential …