Advancing therapy for neuroblastoma
B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …
ranging from localized or spontaneously regressing to widely metastatic disease …
Overview of the 2022 WHO classification of paragangliomas and pheochromocytomas
This review summarizes the classification of tumors of the adrenal medulla and extra-
adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and …
adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and …
[HTML][HTML] Recent advances in the developmental origin of neuroblastoma: an overview
M Ponzoni, T Bachetti, MV Corrias, C Brignole… - Journal of Experimental …, 2022 - Springer
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …
undergoing a defective differentiation due to genomic and epigenetic impairments …
[HTML][HTML] Neuroblastoma: When differentiation goes awry
M Zeineldin, AG Patel, MA Dyer - Neuron, 2022 - cell.com
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …
[HTML][HTML] Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
IS Fetahu, W Esser-Skala, R Dnyansagar… - Nature …, 2023 - nature.com
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …
Schwann cell precursors represent a neural crest‐like state with biased multipotency
ME Kastriti, L Faure, D Von Ahsen… - The EMBO …, 2022 - embopress.org
Schwann cell precursors (SCPs) are nerve‐associated progenitors that can generate
myelinating and non‐myelinating Schwann cells but also are multipotent like the neural …
myelinating and non‐myelinating Schwann cells but also are multipotent like the neural …
[HTML][HTML] A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …
[HTML][HTML] Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
[HTML][HTML] A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia
A Laddach, SH Chng, R Lasrado, F Progatzky… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …
underpinning the neurogenic potential of adult glia are not known. Using single cell …
scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data
Abstract Summary scFates provides an extensive toolset for the analysis of dynamic
trajectories comprising tree learning, feature association testing, branch differential …
trajectories comprising tree learning, feature association testing, branch differential …