B cells encounter both soluble Ag (sAg) and membrane-associated Ag (mAg) in the
secondary lymphoid tissue, yet how the physical form of Ag modulates B cell activation …

Immunoglobulin (Ig) α and Igβ initiate B cell receptor (BCR) signaling through immune
receptor tyrosine activation motifs (ITAMs) that are targets of SH2 domain–containing …

Infection of eukaryotic cells by pathogens requires the efficient use of host cell endocytic and
cytoplasmic transport mechanisms. Understanding how these cellular functions are …

Antigen binding to the B cell antigen receptor (BCR) initiates an array of signaling events.
These include endocytosis of ligand-receptor complexes via clathrin-coated pits, trafficking …

Lipid rafts serve as platforms for BCR signal transduction. To better define the molecular
basis of these membrane microdomains, we used two-dimensional gel electrophoresis and …

The intra‐erythrocytic stages of the malaria parasite endocytose large quantities of the
surrounding erythrocyte cytoplasm and deliver it to a digestive food vacuole via endocytic …

When B cells are exposed to antigens, they use their B‐cell receptors (BCRs) to transduce
this external signal into internal signaling cascades and uptake antigen, which activate …

Introduction B-cell activation triggers the release of endoplasmic reticulum calcium stores
through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by …

The B cell Ag receptor (BCR) can distinguish subtle differences in Ag structure and trigger
differential responses. In this study, we analyzed the effects of Ag valency on the signaling …

Rab proteins are small GTPases involved in the regulation of vesicular membrane traffic.
Research done in the past years has demonstrated that some of these proteins are under …