Antigen capture and presentation onto MHC class II molecules by B lymphocytes is
mediated by their surface antigen receptor—the B-cell receptor (BCR). The BCR must …

Actin cytoskeleton controls a vast range of cellular processes such as motility, cytokinesis,
differentiation, vesicle transport, phagocytosis, muscle contraction. A growing literature …

Early endosomes (EEs) are known to be a sorting station for internalized molecules destined
for degradation, recycling, or other intracellular organelles. Segregation is an essential step …

Intracellular traffic of human P-glycoprotein (P-gp), a membrane transporter responsible for
multidrug resistance in cancer chemotherapy, was investigated using a P-gp and enhanced …

Antigen‐specific B‐cell responses require endosomal trafficking to regulate antigen uptake
and presentation to helper T cells, and to control expression and signaling of immune …

As the central hub of the metabolism machinery, the mammalian target of rapamycin
complex 2 (mTORC2) has been well studied in lymphocytes. As an obligatory component of …

Actin is an important cytoskeletal protein involved in signal transduction, cell structure and
motility. Actin regulators include actin-monomer-binding proteins, Wiskott-Aldrich syndrome …

Signaling via phosphoinositide 3‐kinases (PI3Ks) has emerged as a central component of
lymphocyte activation via immunoreceptors, costimulatory receptors, cytokine receptors, and …

Upon recognizing cognate antigen, B cells mobilize multiple cellular apparatuses to
propagate an optimal response. Antigen binding is transduced into cytoplasmic signaling …

The BCR serves as both signal transducer and Ag transporter. Binding of Ags to the BCR
induces signaling cascades and Ag processing and presentation, two essential cellular …