Melatonin and health: insights of melatonin action, biological functions, and associated disorders
Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …
living organisms. In human beings, pineal gland is the major site for melatonin production …
Melatonin: a multitasking molecule
Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …
distributed and functionally diverse molecule. The mechanisms that control its synthesis …
Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome
M Koziróg, AR Poliwczak, P Duchnowicz… - Journal of pineal …, 2011 - Wiley Online Library
Experimental studies have proven that melatonin has many beneficial pleiotropic actions.
The aim of this study was to assess melatonin efficacy in patients with metabolic syndrome …
The aim of this study was to assess melatonin efficacy in patients with metabolic syndrome …
Melatonin as a free radical scavenger in the ovarian follicle
H Tamura, A Takasaki, T Taketani, M Tanabe… - Endocrine …, 2013 - jstage.jst.go.jp
This review summarizes new findings related to beneficial effects of melatonin (N-acetyl-5-
methoxytryptamine) on reproductive physiology. Recently many researchers have begun to …
methoxytryptamine) on reproductive physiology. Recently many researchers have begun to …
Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression
Obesity has become an epidemic in industrialized and developing countries. In 30 years,
unless serious changes are made, a majority of adults and many children will be classified …
unless serious changes are made, a majority of adults and many children will be classified …
Melatonin as a potential approach to anxiety treatment
Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …
physical symptoms may disturb social and occupational life and increase the risk of somatic …
Melatonin suppresses tumor angiogenesis by inhibiting HIF‐1α stabilization under hypoxia
SY Park, WJ Jang, EY Yi, JY Jang… - Journal of pineal …, 2010 - Wiley Online Library
Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases, resulting in hypoxia in the cancer …
distances from the existing vascular supply increases, resulting in hypoxia in the cancer …
Neurotoxins: free radical mechanisms and melatonin protection
RJ Reiter, LC Manchester… - Current …, 2010 - ingentaconnect.com
Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …
Peripheral and central effects of melatonin on blood pressure regulation
O Pechanova, L Paulis, F Simko - International journal of molecular …, 2014 - mdpi.com
The pineal hormone, melatonin (N-acetyl-5-methoxytryptamine), shows potent receptor-
dependent and-independent actions, which participate in blood pressure regulation. The …
dependent and-independent actions, which participate in blood pressure regulation. The …
Melatonin and pathological cell interactions: Mitochondrial glucose processing in cancer cells
Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …