Nitric oxide (NO), a highly reactive gasotransmitter, is critical for a number of cellular
processes and has multiple biological functions. Due to its limited lifetime and diffusion …

Background Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The
cause and the pathophysiology of the disease are not fully understood and we therefor aim …

Nitric oxide (NO) is known as an unstable signaling molecule that can be produced by three
different NO synthase (NOS) isoforms. It plays a vital role in a wide range of physiological …

Transfusion of RBCs is often clinically necessary—and life-saving—for anemic patients.
RBCs can be stored for up to 42 days between the time of donation and the time of …

Ageing is a natural ontogenetic phenomenon that entails a decrease in the adaptive
capacity of the organism, as a result of which the body becomes less adaptable to stressful …

The endothelium is a mechanosensitive organ whose pleiotropic actions regulate vessel
structure to adjust tissue perfusion. To do so, it possesses ion channels, receptor complexes …

The accumulation of homocysteine (Hcy) during chronic kidney failure (CKD) can exert toxic
effects on the glomeruli and tubulo-interstitial region. Among the potential mechanisms, the …

Background: Cardiovascular diseases (CVDs) are a leading risk factor for mortality
worldwide and the number of CVDs victims is predicted to rise through 2030. While several …

The vascular endothelium is a multifunctional cellular system which directly influences blood
components and cells within the vessel wall in a given tissue. Importantly, this cellular …

Blood pressure (BP) control is a key target for interventions to reduce cognitive decline. This
cross-sectional study explored associations between objective (24-hour urine excretion) and …