The role of microbiota in health and diseases is being highlighted by numerous studies
since its discovery. Depending on the localized regions, microbiota can be classified into …

Conceptual scientific and medical advances have led to a recent realization that there may
be no single, one-size-fits-all diet and that differential human responses to dietary inputs …

Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides
crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota …

Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated
transformation to generate a large pool of bioactive molecules. Although bile acids are …

Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …

The gut bacterium Akkermansia muciniphila has been increasingly recognized for its
therapeutic potential in treating metabolic disorders, including obesity, diabetes, and …

Hyocholic acid (HCA) and its derivatives are found in trace amounts in human blood but
constitute approximately 76% of the bile acid (BA) pool in pigs, a species known for its …

Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …

Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy
balance and host metabolism via G protein-coupled receptors and/or nuclear receptors …