Background Diabetic retinopathy (DR) is a significant complication of diabetes and the
primary cause of blindness among working age adults globally. The development of DR is …

Age-related Macular Degeneration (AMD) is a multifactorial ocular pathology that destroys
the photoreceptors of the macula. Two forms are distinguished, dry and wet AMD, with …

Retinitis pigmentosa is a common cause of inherited blindness in adults, which in many
cases is associated with an increase in the formation of reactive oxygen species (ROS) that …

Polyunsaturated fatty acids (PUFAs) affect several physiological processes, including visual
acuity, but their relationship with diabetic retinopathy (DR) remains elusive. The aim of this …

Purpose Bietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease
caused by mutations in the CYP4V2 gene. Currently, there is no clinical therapy approach …

Tumor cells are characterized by a delicate balance between elevated oxidative stress and
enhanced antioxidant capacity. This intricate equilibrium, maintained within a threshold …

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that exerts physiological effects via G
protein-coupled receptor 120 (GPR120). In our previous studies, we figured out the …

Background An imbalance in lipid metabolism has been linked to the development of AMD,
but the causal relationship between AMD and plasma fatty acids (FAs) remains …

Purpose: Patients deficient in peroxisomal β-oxidation, which is essential for the synthesis of
docosahexaenoic acid (DHA, C22: 6n-3) and breakdown of very-long-chain polyunsaturated …

One of the functions of peroxisomes is the oxidation of fatty acids (FAs). The importance of
this function in our lives is evidenced by the presence of peroxisomal disorders caused by …