Insulin resistance is a multi-faceted disruption of the communication between insulin and the
interior of a target cell. The underlying cause of insulin resistance appears to be …

Obesity leads to various changes in the body. Among them, the existing inflammatory
process may lead to an increase in the production of reactive oxygen species (ROS) and …

Worldwide, and especially in Western civilizations, most of the staple diets contain high
amounts of fat and refined carbohydrates, leading to an increasing number of obese …

A growing body of evidence supports an intriguing clinical/epidemiological connection
between Alzheimer disease (AD) and type 2 diabetes (T2D). T2D patients have significantly …

The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded
protein response (UPR), is an adaptive response used to align ER functional capacity with …

Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …

The goal this review is to clarify the effects of the fat mass and obesity-associated protein
(FTO) in lipid metabolism regulation and related underlying mechanisms through the FTO …

Under physiological conditions, the brain consumes over 20% of the whole body energy
supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries …

Body weight is regulated by interoceptive neural circuits that track energy need, but how the
activity of these circuits is altered in obesity remains poorly understood. Here we describe …

The consumption of W estern diets, high in sugar and saturated fat, is a crucial contributor to
the alarming incidence of obesity and its associated morbidities. These diets have been …