Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …

Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

The epithelial to mesenchymal transition (EMT) has been proposed to contribute to the
metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a …

Abstract Three-dimensional (3D) epigenome remodeling is an important mechanism of gene
deregulation in cancer. However, its potential as a target to counteract therapy resistance …

Kisspeptin neurons residing in the rostral periventricular area of the third ventricle (KPRP3V)
and the arcuate nucleus (KPARC) mediate positive and negative estrogen feedback …

Notch signaling dysregulation encourages breast cancer progression through different
mechanisms such as stem cell maintenance, cell proliferation and migration/invasion …

Much is known about estrogen action in experimental animal models and in human
physiology. This article reviews the mechanisms of estrogen activity in animals and humans …

BRIP1 (Breast Cancer 1 Interacting Helicase 1) is a tumor suppressor gene that has vital
function in preserving the genetic stability by repairing DNA damage though have significant …

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found
in solid tumors. 3D spheroid culture methods recreate more physiologically relevant …

Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast
cancer, the subtype triple-negative lacks expression of major differentiation markers, eg …