The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

Abstract Rho GTPase-activating proteins (RhoGAPs) have been reported to be of great
importance in the initiation and development of many different cancers. However, their …

Cancer is one of the life-threatening disorders that, in spite of excellent advances in
medicine and technology, there is no effective cure for. Surgery, chemotherapy, and …

Etomidate (ETO) is a commonly used intravenous anesthetic that has been reported to exert
a tumor suppressive effect in several types of cancer. The present study aimed to investigate …

Alternative splicing within a gene can create different versions of an mRNA, called isoforms.
CFIm, composed of a small subunit CFIm25 and two large subunits CFIm68 and CFIm59 …

WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular
biological activities through ubiquitination and degradation of its substrates. Recently …

Hepatocellular carcinoma (HCC) is a common liver cancer that accounts for 90% of cases.
Doxorubicin exhibits a broad spectrum of antitumor activity and is one of the most active …

WW domain containing E3 Ub-protein ligase 2 (WWP2) plays an important role in tumor
progression as an E3 ligase of PTEN. Here, we investigated the role of WWP2 in gastric …

WW domain containing E3 ubiquitin protein ligase 2 (WWP2) is a member of the NEDD4 E3
ubiquitin ligase family. WWP2 ligase activity is regulated by the 2, 3‐linker auto‐inhibition …