Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

Integrated spatially resolved metabolomics and network toxicology to investigate the hepatotoxicity mechanisms of component D of Polygonum multiflorum Thunb

HY Jiang, HY Gao, J Li, TY Zhou, ST Wang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance The liver toxicity of Reynoutria multiflora (Thunb.)
Moldenke.(Polygonaceae)(Polygonum multiflorum Thunb, PM) has always attracted much …

[HTML][HTML] 基质辅助激光解吸电离-质谱成像技术(MALDI-MSI) 及其在脑神经性疾病研究中的应用

金涛, 潘本松, 聂洪港 - 计量科学与技术, 2022 - jlkj.nim.ac.cn
大脑是人体内结构最精细, 功能最复杂的高级器官, 其化学物质种类众多, 功能多样,
作用机制复杂. 研究证明, 脑中枢神经系统疾病的病变脑组织都涉及到一些神经分子的改变 …

Applications of engineered skin tissue for cosmetic component and toxicology detection

M Wang, L Zhang, H Hao, M Yan… - Cell Transplantation, 2024 - journals.sagepub.com
The scale of the cosmetic market is increasing every day. There are many safety risks to
cosmetics, but they benefit people at the same time. The skin can become red, swollen …

Mass spectrometry imaging: new eyes on natural products for drug research and development

J Hou, Z Zhang, W Wu, Q He, T Zhang, Y Liu… - Acta Pharmacologica …, 2022 - nature.com
Natural products (NPs) and their structural analogs represent a major source of novel drug
development for disease prevention and treatment. The development of new drugs from NPs …

The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis

M Chen, S Chen, X Wang, Z Ye, K Liu, Y Qian… - Particle and Fibre …, 2024 - Springer
Background Recently, carbon quantum dots (CQDs) have been widely used in various
fields, especially in the diagnosis and therapy of neurological disorders, due to their …

State-of-the-art application of mass spectrometry imaging covering the medicinal and edible plants

Q Jing, H Wang, X Li, D Cui, Y Zhao, W Wang… - TrAC Trends in …, 2024 - Elsevier
Modern researches on medicines and foods have proposed greatly increasing demand on
the spatial distribution analysis of the medicinal and edible plants (MEPs). Mass …

Mass spectrometry imaging as a promising analytical technique for herbal medicines: an updated review

J Zhang, Z Mao, D Zhang, L Guo, H Zhao… - Frontiers in …, 2024 - frontiersin.org
Herbal medicines (HMs) have long played a pivotal role in preventing and treating various
human diseases and have been studied widely. However, the complexities present in HM …

Potential application of mass spectrometry imaging in pharmacokinetic studies

CK Nwabufo, OP Aigbogun - Xenobiotica, 2022 - Taylor & Francis
Although liquid chromatography-tandem mass spectrometry is the gold standard analytical
platform for the quantification of drugs, metabolites, and biomarkers in biological samples, it …

Chloropicrin Ocular Injury: Biomarkers, Potential Mechanisms, and Treatments

EOM Okoyeocha, N Tewari-Singh - Toxicology Letters, 2024 - Elsevier
Ocular tissue, especially the cornea, is overly sensitive to chemical exposures. The
availability and adoption of chemical threat agent chloropicrin (CP) is growing in the United …