Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Simple Summary Colorectal cancer is one of the most frequent and lethal types of cancer.
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …

Colorectal cancer (CRC) is a prevalent and potentially fatal disease categorized based on
its high incidences and mortality rates, which raised the need for effective diagnostic …

Head and neck cancers (HNC) are the seventh most prevalent cancer type globally. Despite
their common categorisation, HNCs are a heterogeneous group of malignancies arising in …

Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …

Basic pre-clinical research based on 2D cultures have been very valuable in colorectal
cancer (CRC) research but still have failed to improve patient prognostic outcomes. This is …

Simple Summary Colorectal cancer is an increasingly prevalent disease that accounts for
substantial mortality and morbidity and is responsible for an impaired quality of life. This …

Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …