The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Within druggable target space, new small-molecule modalities, particularly covalent
inhibitors and targeted degraders, have expanded the repertoire of medicinal chemists …

Most human proteins lack chemical probes, and several large-scale and generalizable small-
molecule binding assays have been introduced to address this problem. How compounds …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors.
Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK …

Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile
way to discover ligands for proteins in native biological systems. Here, we describe a set of …

Covalent chemistry represents an attractive strategy for expanding the ligandability of the
proteome, and chemical proteomics has revealed numerous electrophile-reactive cysteines …

JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in
treating complex diseases such as cancers and immune-mediated disorders. However, their …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived
from ATP hydrolysis to remodel DNA and RNA substrates. These enzymes have key roles in …