Preclinical models for Alzheimer's disease: past, present, and future approaches

A Akhtar, SM Gupta, S Dwivedi, D Kumar… - ACS …, 2022 - ACS Publications
A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

[HTML][HTML] Effects of aluminium contamination on the nervous system of freshwater aquatic vertebrates: a review

M Closset, K Cailliau, S Slaby, M Marin - International Journal of …, 2021 - mdpi.com
Aluminium (Al) is the most common natural metallic element in the Earth's crust. It is
released into the environment through natural processes and human activities and …

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

AV Skalny, M Aschner, Y Jiang, YG Gluhcheva… - Advances in …, 2021 - Elsevier
Recent studies have demonstrated that brain may be considered as the target for aluminium
(Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental …

Aluminum-induced oxidative stress and neurotoxicity in grass carp (Cyprinidae—Ctenopharingodon idella)

ML Fernández-Dávila, AC Razo-Estrada… - Ecotoxicology and …, 2012 - Elsevier
Aluminum is used in a large number of anthropogenic processes, leading to aquatic
ecosystems pollution. Diverse studies show that in mammals this metal may produce …

Aluminum-induced oxidative stress in lymphocytes of common carp (Cyprinus carpio)

S García-Medina, AC Razo-Estrada… - Fish physiology and …, 2010 - Springer
Several studies of fish have shown that aluminum may induce hypoxia, hypercapnia,
metabolic acidosis, and respiratory failure. In lymphocytes, morphologic abnormalities and …

Does neurotransmission impairment accompany aluminium neurotoxicity?

PP Gonçalves, VS Silva - Journal of Inorganic Biochemistry, 2007 - Elsevier
Neurobehavioral disorders, except their most overt form, tend to lie beyond the reach of
clinicians. Presently, the use of molecular data in the decision-making processes is limited …

[PDF][PDF] A systematic review on oxidant/antioxidant imbalance in aluminium toxicity

A Mohammadirad, M Abdollahi - Int J Pharmacol, 2011 - academia.edu
The purpose of this study was to provide a systematic review on the animal or human
evidences linking aluminium (Al) toxicity to oxidant'antioxidant imbalance. Embase, Scopus …

Topiramate confers neuroprotection against methylphenidate-induced neurodegeneration in dentate gyrus and CA1 regions of hippocampus via CREB/BDNF …

M Motaghinejad, M Motevalian, M Abdollahi… - Neurotoxicity …, 2017 - Springer
Methylphenidate (MPH) abuse can cause serious neurological damages. The
neuroprotective effects of topiramate (TPM) have been reported already, but its mechanism …

Metals and nonsteroidal anti-inflammatory pharmaceuticals drugs present in water from Madín Reservoir (Mexico) induce oxidative stress in gill, blood, and muscle of …

ED González-González, LM Gómez-Oliván… - Archives of …, 2014 - Springer
Many toxic xenobiotics that enter the aquatic environment exert their effects through redox
cycling. Oxidative stress, which incorporates both oxidative damage and antioxidant …

Protective role of lithium during aluminium-induced neurotoxicity

P Bhalla, ML Garg, DK Dhawan - Neurochemistry international, 2010 - Elsevier
The present study was designed to examine the protective potential of lithium if any in
ameliorating the alterations induced by aluminium (Al) on behavioral and neurochemical …