The activation of phagocytic cells is a hallmark of many neurological diseases. Imaging them
in their 3-dimensional cerebral environment over time is crucial to better understand their …

Biological tissues comprise a spatially complex structure, composition and organization at
the microscale, named the microstructure. Given the close structure-function relationships in …

Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-
threatening conditions that slowly deteriorate quality of life and for which our diagnostic …

High-contrast, high-resolution imaging of biomedical specimens is indispensable for
studying organ function and pathologies. Conventional histology, the gold standard for soft …

Historically, micro-computed tomography (μCT) has been considered unsuitable for
histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue biopsy …

Background: Micrometer-resolution neuroimaging with gold-standard conventional histology
requires tissue fixation and embedding. The exchange of solvents for the creation of …

Phase-contrast imaging techniques address the issue of poor soft-tissue contrast
encountered in traditional X-ray imaging. This can be accomplished with the propagation …

We investigate structural properties of neurons in the granular layer of human cerebellum
with respect to their involvement in multiple sclerosis (MS). To this end we analyze data …

Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent
bidimensionality limits histological procedures' effectiveness in identifying these changes …

Background The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which
still has one of the lowest survival rates, requires novel imaging tools to improve early …