Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …

The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …

Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated
protein 13 (Cas13) has been rapidly developed for nucleic-acid-based diagnostics by using …

Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …

Abstract Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein
family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral …

We review the structures and functions of ADARs and their involvements in human diseases.
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …

Adenosine deaminases acting on RNA (ADARs) are RNA editing enzymes that catalyze the
hydrolytic deamination of adenosine (A) to inosine (I) in dsRNA. In humans, two catalytically …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

It is well known that the stability of RNA, the interaction between RNA and protein, and the
correct translation of protein are significant forces that drive the transition from normal cell to …