Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Hepatic macrophages are central in the pathogenesis of chronic liver injury and have been
proposed as potential targets in combatting fibrosis. Recent experimental studies in animal …

An overdose of acetaminophen (N-acetyl-p-aminophenol, APAP), also termed paracetamol,
can cause severe liver damage, ultimately leading to acute liver failure (ALF) with the need …

Macrophages constitute a major proinflammatory component during chronic liver diseases
and are considered a key factor in promoting hepatic fibrosis. However, there is increasing …

Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has
long been suspected in the pathogenesis of atherosclerosis; however, the molecular …

Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation
process consisting in altered deposition of extracellular matrix. Progression of fibrosis can …

Blood monocytes are precursors of dendritic cells, macrophages, and osteoclasts. They are
a heterogeneous cell population with differences in size, phenotype, and function. Although …

Background and Aims During liver fibrosis, liver sinusoidal endothelial cells (LSECs)
release angiocrine signals to recruit inflammatory cells into the liver. p300, a master …