Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of
kynurenic acid, anthranilic acid and 3-hydroxykynurenine (3-HK). Under physiological …

Stem Cell Antigen-1 (Sca-1/Ly6A) was the first identified member of the Lymphocyte antigen-
6 (Ly6) gene family. Sca-1 serves as a marker of cancer stem cells and tissue resident stem …

Hepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic
heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently …

NAD+ metabolism is implicated in aging and cancer. However, its role in immune checkpoint
regulation and immune evasion remains unclear. Here, we find nicotinamide …

Metabolic enzymes and metabolites display non-metabolic functions in immune cell
signalling that modulate immune attack ability. However, whether and how a tumour's …

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and
available therapies, including immunotherapies, are ineffective for many patients. HCC is …

Ferroptosis is a non-apoptotic, iron-dependent oxidative form of cell death that is specifically
induced by erastin in RAS mutant cancer cells. Ferroptotic cell death is the result of …

Defective pericyte-endothelial cell interaction in tumors leads to a chaotic, poorly organized
and dysfunctional vasculature. However, the underlying mechanism behind this is poorly …

Although emerging cell-or animal-based evidence supports the relationship between SND1
and cancers, no pan-cancer analysis is available. We thus first explored the potential …

Objective Hepatocellular carcinoma (HCC) represents a typical inflammation-associated
cancer. Tissue resident innate lymphoid cells (ILCs) have been suggested to control tumour …