Objective: To review the basis for the estimated comparative daily dosages of inhaled
corticosteroids for children and adults that are presented in the National Heart, Lung, and …

Introduction Pharmacological asthma management focuses on the use of inhaled
corticosteroid (ICS)-containing therapies, which reduce airway inflammation and provide …

Aims To compare the airway potency, systemic activity and therapeutic index of three
inhaled corticosteroids that differ in glucocorticoid receptor binding affinity, physicochemical …

Background Epidemiological evidence suggests that hookworm infection protects against
asthma. However, for ethical and safety reasons, before testing this hypothesis in a clinical …

Introduction This study compared the bronchoprotective and benefit/risk profiles of various
inhaled corticosteroid (ICS) dosing regimens in mild asthma. Methods A pharmacokinetic …

Ciclesonide provides a newer ICS with favorable pharmacokinetics that may improve the
therapeutic index, but assessment of its systemic effects such as growth await further …

Background: It is important to be able to compare the efficacy and systemic effects of inhaled
corticosteroids but their slow onset of action makes it difficult to measure the maximum …

Background: Ciclesonide exhibits clinical efficacy at 160 μg (ex‐actuator) once daily but the
anti‐inflammatory effects at this dose are not known. We wished to know whether 4 weeks …

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Two recent trials from the National Heart, Lung, and Blood Institute's asthma clinical trials
networks raise a concern about using double the dose of an inhaled corticosteroid (ICS) as …