A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

Multiple sclerosis is a common and frequently disabling neurological disease of young
adults. It is characterised by recurrent areas of focal inflammation (plaques) in the CNS …

Oligodendrocyte death contributes to the pathogenesis of the inflammatory demyelinating
disease multiple sclerosis (MS). Nevertheless, current MS therapies are mainly …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) in young adults that has serious negative socioeconomic effects. In addition to …

Abstract TRPM4 is a Ca 2+-activated nonselective cation channel. The channel is activated
by an increase of intracellular Ca 2+ and is regulated by several factors including …

Several lines of evidence strongly implicate type I interferons (IFN-α and β) and IFN-
signaling in the pathogenesis of certain autoimmune inflammatory diseases. Accordingly …

Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system
(CNS). Its corresponding animal model, experimental autoimmune encephalomyelitis (EAE) …

Upregulation and/or maintenance of regulatory T cells (Tregs) during an autoimmune insult
may have therapeutic efficacy in autoimmune diseases. Although several …

In multiple sclerosis (MS) and other autoimmune diseases, the autoreactive T cells
overcome the resistance provided by the regulatory T cells (Tregs) due to a decrease in the …

Objective: Some evidence suggests that chronic uptake of estragole and methyl-eugenol,
found in the essential oil of Artemisia dracunculus (tarragon), may be associated with an …