Systemic inflammation after stroke: implications for post‐stroke comorbidities

A Simats, A Liesz - EMBO molecular medicine, 2022 - embopress.org
Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Glymphatic dysfunction in patients with ischemic stroke

CH Toh, TY Siow - Frontiers in aging neuroscience, 2021 - frontiersin.org
Objectives: Rodent experiments have provided some insight into the changes of glymphatic
function in ischemic stroke. The diffusion tensor image analysis along the perivascular …

Research evidence of the role of the glymphatic system and its potential pharmacological modulation in neurodegenerative diseases

JP Verghese, A Terry, ER de Natale… - Journal of Clinical …, 2022 - mdpi.com
The glymphatic system is a unique pathway that utilises end-feet Aquaporin 4 (AQP4)
channels within perivascular astrocytes, which is believed to cause cerebrospinal fluid …

Acutely inhibiting AQP4 with TGN-020 improves functional outcome by attenuating edema and peri-infarct astrogliosis after cerebral ischemia

C Sun, L Lin, L Yin, X Hao, J Tian, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Ischemic stroke is one of the leading causes of human death and disability.
Brain edema and peri-infarct astrocyte reactivity are crucial pathological changes, both …

The mechanism of ferroptosis in early brain injury after subarachnoid hemorrhage

X Deng, Y Wu, Z Hu, S Wang, S Zhou, C Zhou… - Frontiers in …, 2023 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a cerebrovascular accident with an acute onset, severe
disease characteristics, and poor prognosis. Within 72 hours after the occurrence of SAH, a …

Glymphatic system: an emerging therapeutic approach for neurological disorders

Y Gao, K Liu, J Zhu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The functions of the glymphatic system include clearance of the metabolic waste and
modulation of the water transport in the brain, and it forms a brain-wide fluid network along …

Stroke and neurogenesis: bridging clinical observations to new mechanistic insights from animal models

JP Passarelli, SM Nimjee, KL Townsend - Translational stroke research, 2024 - Springer
Stroke was the 2nd leading cause of death and a major cause of morbidity. Unfortunately,
there are limited means to promote neurological recovery post-stroke, but research has …

[Retracted] Aquaporin 4 Depolarization‐Enhanced Transferrin Infiltration Leads to Neuronal Ferroptosis after Subarachnoid Hemorrhage in Mice

Y Liu, Z Wang, C Cao, Z Xu, J Lu… - Oxidative Medicine …, 2022 - Wiley Online Library
The infiltration of blood components into the brain parenchyma through the lymphoid system
is an important cause of subarachnoid hemorrhage injury. AQP4, a water channel protein …

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Y Qin, X Li, Y Qiao, H Zou, Y Qian, X Li, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Purpose Brain glymphatic dysfunction is involved in the pathologic process of acute
ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in …