SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

SARS-CoV-2 and the host cell: a tale of interactions

M Pizzato, C Baraldi, G Boscato Sopetto… - Frontiers in …, 2022 - frontiersin.org
The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1

J Chai, Y Cai, C Pang, L Wang, S McSweeney… - Nature …, 2021 - nature.com
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has created global health and
economic emergencies. SARS-CoV-2 viruses promote their own spread and virulence by …

Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2

U Breitinger, NS Farag, H Sticht… - The international journal of …, 2022 - Elsevier
Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …

[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development

S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …

COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy

D Kumar, S Verma, IU Mysorekar - Translational Research, 2023 - Elsevier
As the COVID-19 pandemic continues into its third year, emerging data indicates increased
risks associated with SARS-CoV-2 infection during pregnancy, including pre-eclampsia …

pH-and calcium-dependent aromatic network in the SARS-CoV-2 envelope protein

J Medeiros-Silva, NH Somberg, HK Wang… - Journal of the …, 2022 - ACS Publications
The envelope (E) protein of the SARS-CoV-2 virus is a membrane-bound viroporin that
conducts cations across the endoplasmic reticulum Golgi intermediate compartment …

[HTML][HTML] Endocytosis and transcytosis of SARS-CoV-2 across the intestinal epithelium and other tissue barriers

E Knyazev, S Nersisyan, A Tonevitsky - Frontiers in immunology, 2021 - frontiersin.org
Since 2003, the world has been confronted with three new betacoronaviruses that cause
human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome …

Distinct motifs in the E protein are required for SARS-CoV-2 virus particle formation and lysosomal deacidification in host cells

K Miura, Y Suzuki, K Ishida, M Arakawa, H Wu… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a major public health
concern, but the mechanisms underlying its viral particle formation are not well understood …

Airway epithelial cell junctions as targets for pathogens and antimicrobial therapy

N Gao, F Rezaee - Pharmaceutics, 2022 - mdpi.com
Intercellular contacts between epithelial cells are established and maintained by the apical
junctional complexes (AJCs). AJCs conserve cell polarity and build epithelial barriers to …