Role of primary intrahepatic T‐cell activation in the 'liver tolerance effect'

P Bertolino, GW McCAUGHAN… - Immunology and cell …, 2002 - Wiley Online Library
There is accumulating evidence suggesting that hepatic permeability to both naive and
activated T lymphocytes may be unique among the solid organs. The possibility that the liver …

Antiviral chemotherapy for the treatment of hepatitis B virus infections

J Torresi, S Locarnini - Gastroenterology, 2000 - Elsevier
Approximately 5% of the world's human population have an increased risk for developing
liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B …

Antigen-specific primary activation of CD8+ T cells within the liver

P Bertolino, DG Bowen, GW McCaughan… - The Journal of …, 2001 - journals.aai.org
It is generally accepted that naive T cells recirculate via the blood and lymph, but do not
enter nonlymphoid tissues without prior activation and differentiation. In this study, we …

HBV virological assessment

A Hatzakis, E Magiorkinis, C Haida - Journal of hepatology, 2006 - Elsevier
Management of hepatitis B virus (HBV) infected patients involves serological diagnosis,
quantitation of HBV–DNA and measurement of HBV drug resistance. Different serological …

Serum gamma‐interferon‐inducing factor (IL‐18) and IL‐10 levels in patients with acute hepatitis and fulminant hepatic failure

E Yumoto, T Higashi, K Nouso… - Journal of …, 2002 - Wiley Online Library
Abstract Background and Aims: The aim was to determine the role of T‐helper (Th) 1/Th2
cytokine responses in the clinical outcome of patients with acute liver injury. Methods: The …

Adaptive immune responses during acute uncomplicated and fulminant hepatitis E

R Srivastava, R Aggarwal, S Sachdeva… - Journal of …, 2011 - Wiley Online Library
Abstract Background and Aim: Hepatitis E virus (HEV) infection is endemic in several
developing countries. Clinical manifestations of this infection vary widely from asymptomatic …

Expression of a full-length hepatitis C virus cDNA up-regulates the expression of CC chemokines MCP-1 and RANTES

HM Soo, A Garzino-Demo, W Hong, YH Tan, YJ Tan… - Virology, 2002 - Elsevier
We had previously reported the cloning of the complete genome of an isolate of hepatitis C
virus (HCV), HCV-S1, of genotype 1b. We have constructed a full-length complementary …

In vivo and in vitro induction of MxA protein in peripheral blood mononuclear cells from patients chronically infected with hepatitis C virus

M Fernández, JA Quiroga, J Martin… - The Journal of …, 1999 - academic.oup.com
To test whether (HCV) persistence is related to interferon (IFN) hyporesponsiveness,
peripheral blood monuclear cells from 29 patients and 11 controls were studied for MxA …

Outcome of renal transplantation in hepatitis B surface antigen‐positive patients after introduction of lamivudine

SK Park, WS Yang, YS Lee, HH Jung… - Nephrology Dialysis …, 2001 - academic.oup.com
Background. In end‐stage renal disease patients with hepatitis B surface antigen (HBsAg),
the risk of hepatic dysfunction after immunosuppression represents a large barrier in renal …

[PDF][PDF] Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

NA Osna, DL Clemens, TM Donohue Jr - Hepatology, 2005 - Wiley Online Library
We previously showed that IFNγ signal transduction was suppressed by ethanol in
recombinant HepG2 cells (VL‐17A cells), which express alcohol dehydrogenase (ADH) and …