Abstract Introduction Frailty Index (FI) is a common measure of frailty, which has been
advocated as a routine clinical test by many guidelines. The genetic and phenotypic …

Background Major depressive disorder (MDD) and bipolar disorder (BD) are prevalent
psychiatric conditions linked to inflammatory processes. However, it is unclear whether …

This study aimed to assess the association between dietary factors and depression in a
group of polycystic ovary syndrome (PCOS) women and to evaluate potential interactions …

Aims While observational studies have suggested associations linking aging and mental
disorders, the question of causality has remained unclear. This study aimed to explore the …

Background Observational studies have shown that neuroticism is associated with frailty, but
the causal relationship between them remains unclear. Methods A two-sample Mendelian …

Aim To explore the prevalence of social isolation among Japanese community‐dwelling
older adults before and during the COVID‐19 pandemic as well as determine how family …

Background Frailty has been associated with mental illness (MI) observational studies, but
the causal relationship between these factors remains uncertain. We aimed to assess the …

Controversial findings regarding the association between serum cholesterol levels and
Alzheimer's disease (AD) have been identified through observational studies. The genetic …

Background Frailty is a common geriatric syndrome associated with reduced reserves and
increased vulnerability to stressors among older adults. Vitamin D deficiency has been …

This study aimed to examine joint trajectories of pain, depression and frailty and their
associations with adverse outcomes. Four waves of national data from the China Health and …