Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

After more than a decade of method development, cross-linking in combination with mass
spectrometry and bioinformatics is finally coming of age. This technology now provides …

Knowledge of elaborate structures of protein complexes is fundamental for understanding
their functions and regulations. Although cross-linking coupled with mass spectrometry (MS) …

CID-MS/MS cleavable cross-linkers hold an enormous potential for an automated analysis of
cross-linked products, which is essential for conducting structural proteomics studies. The …

Protein–protein interactions (PPIs) are fundamental to the structure and function of protein
complexes. Resolving the physical contacts between proteins as they occur in cells is critical …

Covalently bound azide on a (small) organic molecule or a (large) biomolecular structure
has proven an important handle for bioconjugation. Azides are readily introduced, small …

Cross-linking mass spectrometry has become an established technology to provide
structural information on the topology and dynamics of protein complexes. Readily …

The method of crosslinking combined with mass spectrometry is being gradually accepted
as a technology enabling detailed structural information on proteins and protein complexes …

Chemical cross-linking combined with mass spectrometry (MS) and computational modeling
has evolved as an alternative method to address fundamental questions in structural …