[HTML][HTML] Understanding the role of the gut microbiome and microbial metabolites in non-alcoholic fatty liver disease: current evidence and perspectives

N Vallianou, GS Christodoulatos, I Karampela… - Biomolecules, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non …

[HTML][HTML] Role of gut microbiota in type 2 diabetes pathophysiology

M Gurung, Z Li, H You, R Rodrigues, DB Jump… - …, 2020 - thelancet.com
A substantial body of literature has provided evidence for the role of gut microbiota in
metabolic diseases including type 2 diabetes. However, reports vary regarding the …

[HTML][HTML] Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Y Xu, N Wang, HY Tan, S Li, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a
worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has …

Introduction to the human gut microbiota

E Thursby, N Juge - Biochemical journal, 2017 - portlandpress.com
The human gastrointestinal (GI) tract harbours a complex and dynamic population of
microorganisms, the gut microbiota, which exert a marked influence on the host during …

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

R Duan, X Guan, K Huang, Y Zhang, S Li… - Journal of Agricultural …, 2021 - ACS Publications
A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA)
metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids …

[HTML][HTML] Factors affecting the composition of the gut microbiota, and its modulation

N Hasan, H Yang - PeerJ, 2019 - peerj.com
Gut microbiota have important functions in the body, and imbalances in the composition and
diversity of those microbiota can cause several diseases. The host fosters favorable …

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Y Rao, Z Kuang, C Li, S Guo, Y Xu, D Zhao, Y Hu… - Gut …, 2021 - Taylor & Francis
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its
therapeutic potential in treating metabolic disorders, including obesity, diabetes, and …

Gut microbiota and type 2 diabetes mellitus: Association, mechanism, and translational applications

L Zhang, J Chu, W Hao, J Zhang, H Li… - Mediators of …, 2021 - Wiley Online Library
Gut microbiota has attracted widespread attention due to its crucial role in disease
pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial …

The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury

S Keshavarz Azizi Raftar, F Ashrafian… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed as a next-
generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality …

[HTML][HTML] Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome

A Gao, J Su, R Liu, S Zhao, W Li, X Xu, D Li… - Nature …, 2021 - nature.com
Males are generally more susceptible to impaired glucose metabolism and type 2 diabetes
(T2D) than females. However, the underlying mechanisms remain to be determined. Here …