Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics

S Al Huq Mohammed… - World Academy of …, 2024 - spandidos-publications.com
Protein structure is extraordinarily complex and consists of various folding processes,
namely, primary, secondary, tertiary and quaternary. Currently, researchers are eager to …

Effect of palmitoylethanolamide on inner retinal function in glaucoma: A randomized, single blind, crossover, clinical trial by pattern-electroretinogram

GCM Rossi, L Scudeller, C Lumini, F Bettio… - Scientific Reports, 2020 - nature.com
Glaucoma is a neurodegenerative disease, our study aimed to evaluate the potential effects
of Palmitoylethanolamide (PEA) supplementation on RGCs function by PERG examination …

Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction

H Wu, Y Cui, C He, P Gao, Q Li, H Zhang… - Science China Life …, 2020 - Springer
High salt intake is a known risk factor of cardiovascular diseases. Our recent study
demonstrated that long-term high salt intake impairs transient receptor potential channel M5 …

Sodium tanshinone IIA sulfonate inhibits vascular endothelial cell pyroptosis via the AMPK signaling pathway in atherosclerosis

J Zhu, H Chen, J Guo, C Zha, D Lu - Journal of Inflammation …, 2022 - Taylor & Francis
Introduction Atherosclerosis (AS) is the underlying cause of cardiovascular events.
Endothelial cell mitochondrial damage and pyroptosis are important factors contributing to …

Integration of 16S rRNA sequencing and metabolomics to investigate the modulatory effect of ginsenoside Rb1 on atherosclerosis

Y Liang, J Fu, Y Shi, X Jiang, F Lu, S Liu - Heliyon, 2024 - cell.com
Abstract Background/aims: Atherosclerosis (AS) is the common pathological basis of a
variety of cardiovascular diseases (CVD), and has become the main cause of human death …

Effects of betanin on AMPK, Sirtuin1, and Sirtuin6 gene expression and inflammatory cytokines levels in peripheral blood mononuclear cells of patients with coronary …

N Mahami, N Abedimanesh, S Asghari… - Nutrition & Food …, 2021 - emerald.com
Purpose This study aims to evaluate the effects of betanin on AMP-activated protein kinase
(AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour …

Mitigative impact of bradykinin potentiating factor isolated from Androctonus amoreuxi scorpion venom and low doses of γ-irradiation on doxorubicin induced …

HF Hasan, SM Galal, RA Ellethy - Toxicology Mechanisms and …, 2022 - Taylor & Francis
In this study, the mitigative impact of bradykinin potentiating factor (BPF) and low doses of γ-
irradiation (LDR) were evaluated against doxorubicin (DOX) hepatotoxicity through Ang …

Angiotensin II upregulates endothelin receptors through the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway in vascular smooth muscle cells

X Zhang, H Zhang, X Yang, Q Qin, X Sun… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives This study was designed to test our hypothesis that angiotensin II (Ang II)
upregulates endothelin (ET) receptors in vascular smooth muscle cells (VSMCs). Methods …

mTOR 在糖尿病血管病变中的研究进展

魏姣姣, 刘师伟, 段瑞雪, 吴亚茹, 李楠 - 医学分子生物学杂志, 2023 - tjqk.magtech.com.cn
糖尿病血管病变是糖尿病致残, 致死的主要原因, 然而目前多种治疗策略对糖尿病血管病变的
防治仍未取得理想的结果. 哺乳动物雷帕霉素靶蛋白(mechanistic target of rapamycin kinase …

The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E‐Deficient Mice Is Mediated by miRNA‐21

X Xu, Z Zhao, G Li - BioMed Research International, 2019 - Wiley Online Library
Vascular calcification is an independent risk factor for plaque instability and is associated
with endothelial cell function. Here, we investigated the role of endothelial cell function in the …